Parkinson's Disease Treatment with Nanozymes

Parkinson's disease (PD) is the second most common neurodegenerative disease with high prevalence, it always has a high disability rate, prolonged course and heavy disease burden. At present, treatment strategies for Parkinson's disease mainly include drug therapy, gene therapy, stem cell therapy, and physical stimulation therapy. But all of these treatments have certain shortcomings. Nanozymes therapy has shown unique advantages in solving these problems. They are not only good carriers for drug and gene delivery, but some nanozymes also show neuroprotective effects. Therefore, nanozymes can assist stem cell therapy for PD and are expected to stimulate and regulate neural activity.

Creative Enzymes makes full use of our specialized libraries, selection strategies and maturation techniques to optimize the stability and performance of nanozymes. With advanced technology and experienced staff, we provide a variety of nanozymes for treating Parkinson's disease to global clients to support their research use.

Fig. 1 Directions of research in nanotechnology for the treatment of Parkinson's disease.

Mn₃O₄ Nanozymes in Treating Parkinson's Disease

Creative Enzymes provides Mn₃O₄ nanozymes with antioxidant-enzyme-like catalytic activities, which can play a crucial role in protecting cells from MPP⁺ induced cytotoxicity in a PD-like cellular model.

Cu_xO Nanozymes in Treating Parkinson's Disease

• Since copper serves as a vital component of many important enzymes in living systems, the formed Cu_xO nanozymes exhibit multienzyme-like properties including SOD, CAT, and GPx, which can efficiently remove harmful ROS and protect nerve cells against oxidative stress induced by MPP⁺.
• Inspired by this principle, Creative Enzymes further designs phenylalanine-modified Cu_xO nanozymes for PD treatment.
• After treatment with Cu_xO nanozymes, the objects display strongly enhanced spatial learning, memory, escape latency, and swimming speeds during the training process, indicating that Cu_xO can induce cognitive recovery. Taken together, this powerful Cu_xO antioxidant nanozyme may have great potential for ameliorating neurodegenerative diseases.

Fe₃O₄ Nanozymes in Treating Parkinson's Disease

• Some studies show that Fe₃O₄ nanozymes with magnetic have effects of neuroprotective and anti-inflammatory.
• The abnormal aggregation of alpha-synuclein (α-syn) is an important pathogenesis of PD. We construct Lysine (Lys) -coated Fe₃O₄ nanozymes with strong binding to α-syn, which inhibit the occurrence of early α-syn aggregation. In addition, they accelerate the rate of abnormal protein aggregation.
• The above nanozymes are expected to be treated for PD, but more studies are needed to determine the safety of their use in vivo.

Creative Enzymes offers reliable nanozymes for PD treatment to meet your research demands. With years of experience in nanozymes, our advanced platforms can help our clients solve various difficulties and conduct research. If you are interested in our services or have any questions, please feel free to contact us or make an online inquiry.