Alzheimer's Disease Treatment with Nanozymes

Alzheimer's disease (AD) is a central neurodegenerative disease. As society ages, the prevalence of AD is increasing. The severity of AD is enough to interfere with people's daily lives and endanger human health. At present, the pathogenesis of AD is still unclear, and there is no effective drug to cure AD. Nanozyme drug systems can non-invasively deliver drugs to the brain, reduce drug toxicity and increase drug bioavailability through targeted drug delivery.

CD BioSciences is a leading provider of comprehensive, high-quality services for nanozymes. We offer provides varieties of nanozymes for treating AD with professional teams. We hope to partner with you to explore new frontiers in nanozyme and accelerate your discovery.

CeO₂ Nanozymes in Treating Alzheimer's Disease

• CeO₂ nanozymes possess outstanding SOD- and CAT-like catalytic properties. It can effectively eliminate O²⁻ and H₂O₂ to protect cells from oxidative stress. This is mainly because CeO₂ can bind oxygen atoms in a recyclable way, as well as the rapid conversion between Ce⁴⁺ and Ce³⁺ on the surface of nanozymes.
• CD BioSciences designs triphenyl phosphonium (TPP) -modified CeO₂ nanozymes as a new platform for AD treatment. The obtained nano composite can localize to mitochondria and then eliminate harmful ROS, inhibiting neuronal death.
• Further exploration demonstrates that this system can be used as a new method of mitochondrial therapy for neuroinflammation, which is of great significance for the treatments of Alzheimer's disease and other neurodegenerative diseases.

CeO@POMs Nanozymes in Treating Alzheimer's Disease

• The accumulation of Aβ induced by protein misfolding has been considered the hallmark for neurodegenerative disease.
• By self-assembling CeO₂ nanoparticles and polyoxometalates (POM), we successfully design CeO@POMs hybrid nanomaterials recently.
• The nanocomposites exhibit a SOD-like antioxidant property and can also serve as proteolytic enzyme mimics. In this way, CeO@POMs can efficiently inhibit the aggregation of Aβ as well as decrease the intracellular ROS level.

Fe₃O₄ Nanozymes in Treating Alzheimer's Disease

• Ferromagnetic nanozymes can also be used as a free radical scavenger to relieve ROS-associated neurodegenerative diseases.

Fig. 1 Antioxidant property of Fe₃O₄ nanozymes to ameliorate ROS induced neurodegeneration.

• In the neutral environment, CD BioSciences constructs Fe₃O₄ nanozymes with catalase-like property, which can efficiently scavenge intracellular excessive ROS and protect cells against H₂O₂-induced oxidative damage and apoptosis. In addition, Fe₃O₄ nanozymes have a neuroprotective effect on cells.
• In vivo studies, Fe₃O₄ nanozymes are further found to have excellent antioxidant properties to delay aging and improve ROS-induced neurodegeneration.

CD BioSciences provides a variety of nanozymes for treating AD to our clients worldwide. With years of experience in biological services, our advanced platforms can help our clients solve various difficulties in detecting glutathione with nanozymes. If you are interested in our services or have any questions, please feel free to contact us or make an online inquiry.