Description
Highly cross-linked with seven disulfide bridges, Bowman-Birk inhibitor has spatially distinct domains for trypsin and chymotrypsin inhibition.
Applications
Bowman Birk protease inhibitor prevents radiation-induced carcinogenesis by a reduction of incorrect DNA repairs, resulting in a reduced amount of dicentric chromosomes.
Package
10 mg in glass bottle
25 mg in poly bottle
50, 100, 500 mg in glass bottle
Form
Lyophilized powder containing phosphate buffer salts, pH 7.6
Activity
1 mg protein will inhibit ≥0.5 mg trypsin with activity of ~10,000 BAEE units per mg protein or ≥1.0 mg chymotrypsin with activity of ~40 BTEE units per mg protein.
Composition
Protein, 70-90% biuret
Unit Definition
One trypsin unit = ΔA253 of 0.001 per min with BAEE as substrate at pH 7.6 at 25 °C. Reaction volume = 3.2 mL (1 cm light path).
Synonyms
BOWMAN-BIRK INHIBITOR; TRYPSIN-CHYMOTRYPSIN INHIBITOR; Proteinase inhibitor, BowMan-Birk; trypsin-chymotrypsin inhibitor from*soybean; trypsin-chymotrypsin inhibitor from glycine max (soybean)
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