Description
OAC-1 is an Oct-4 activator which enhances and accelerates iPSC reprogramming in the presence of 4F (Oct-4, Sox-2, c-Myc and GKLF) by ~20-fold (relative to 4F by itself). OAC-1 upregulates mRNA expression of Oct-4, Sox-2 and Nanog, as well as Tet1. It has shown no effects, however, on the p53-p21 pathway or Wnt-β-catenin signaling.
Applications
An Oct-4 activator which increases mRNA expression of Oct-4, Sox-2, Nanog, and Tet1
Synonyms
N-1H-Pyrrolo[2,3-c]pyridin-5-ylbenzamide
Molecular Formula
C14H11N3O
Melting Point
197.05 °C (Predicted)
Boiling Point
~386.6 °C at 760 mmHg (Predicted)
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