Antithrombosis with Nanozymes

Thrombotic diseases, thrombosis or embolism, involve all systemic organs, mainly in heart, brain and peripheral vascular diseases. They have the characteristics of high incidence, high disability and fatal, resulting in serious clinical consequences. The occurrence of thrombotic diseases is related to vascular injury, changes in local blood flow and changes in blood flow components. Antithrombotic therapy, including antiplatelet, anticoagulant and thrombolytic therapy, plays an increasingly important role in the treatment of heart, brain and peripheral vascular diseases.

Creative Enzymes is a credible provider of high-quality antithrombosis services with nanozymes. Our platform is equipped with state-of-the-art facilities and highly experienced staff to support nanozyme projects in all areas. We guarantee to deliver results on time to our customers.

Antithrombosis with Grapheme-Hemein-Glucose Oxidase Nanozymes

• Since nitric oxide (NO) is an effective antiplatelet agent to prevent thrombosis, numerous efforts have been dedicated to the fabrication of polymeric coatings that can release or generate NO. Similar to NO, HNO also has antithrombotic properties. Therefore, the biomimetic generation of HNO from endogenous substances may be one possible way for antithrombosis.

Fig. 1 Grapheme-hemein-glucose oxidase nanozymes for biomimetic generation of HNO. (Xue T, et al., 2014)

• Inspired by these unique properties, Creative Enzymes designs grapheme-hemein-glucose oxidase nanozymes for antithrombosis.
• Grapheme nanosheets are used as the template to assemble glucose oxidase as well as hemein. Glucose oxidase can catalyze endogenous glucose to produce H₂O₂. While the hemein component serves as the nitric oxide synthase enzyme mimic, to further catalyze the oxidation of L-arginine with the assistance of H₂O₂ to generate antithrombotic HNO under physiological environments.

Antithrombosis with Silica Nanozyme

• To develop the antithrombotic is important to sustain the function of biomedical devices, such as heart valves, catheters, and vascular grafts.
• Creative Enzymes constructs silica nanozymes with enormous consideration. In addition to their high biodegradability and biocompatibility, silica nanozymes can selectively modify their outer and inner surfaces to powerfully encapsulate molecules. They can be specifically functions on their outer surface.
• The delivery of this multiple function silica nanozymes in the bloodstream prevents the thrombogenic effects. The coating of ethylene glycol addresses hemolytic behavior and their fast degradation prevention.

Antithrombosis with Ceria-Based Nanozyme

• The application of nanozymes in antithrombotic applications is mainly based on simulated hydrolytic activity and specific catalytic activity.
• Creative Enzymes synthesizes ceria-based MOFs (Uio-66 (Ce)) with intrinsic apyrase-like activity as an antithrombotic coating for blood contacting medical devices.

Fig. 2 Scheme of UiO-66 (Ce) film to suppress platelet adhesion against the ADP inducement of platelet aggregation.

• The surface Ce³⁺ / Ce⁴⁺ couple sites endow Uio-66 (Ce) apyrase-like activity that can catalyze the cleavage of the high-energy phosphate bonds in ADP and ATP. Therefore, Uio-66 (Ce) can modulate ATP / ADP-related physiological processes like ADP-induced platelet aggregation.

Creative Enzymes provides fast turnaround, high quality services at competitive prices for customers worldwide. Our advanced technical platforms can help our clients complete the research process with quality and quantity. If you are interested in our services or have any questions, please feel free to contact us or make an online inquiry.