Nanozymes for Tissue Imaging

An advantage of nanozymes for use in the biomedical imaging field is their editable nature, which allows them to be used as platforms for assembling specific multifunctional structures on demand. These nano-systems still retain good solubility and colloidal properties, and they are suitable for complex environments including blood, tissues, etc. By adjusting the composition of nanozymes and appropriate surface modifications, imaging probes with targeting capabilities in biological systems can be obtained. Nanozymes can be functionalized to provide multimodal applications by modifying different groups such as fluorescent dyes, drugs, targeted ligands, etc.

Nanozymes are widely used in biomedicine and remain a rapidly growing area of research. So far, the focus has been on biological imaging. Creative Enzymes provides a variety of enzymes for tissue imaging, including tumor tissue and pathology tissue, to improve the convenience of medical treatment through biochemistry.

Imaging of Atherosclerotic Plaques with Nanozymes

• Ruptured atherosclerotic plaque, which results in thrombosis and vascular obstruction, is a leading cause of death worldwide. For the treatment of carotid and coronary artery disease, there is an urgent need to identify plaque vulnerabilities.
• Nanozymes with enzyme-like properties have attracted great interest by providing information about the biology, diagnosis and prognosis of diseases. Creative Enzymes has proposed a bioengineered magnetic nanozyme that catalyzes the oxidation of colorimetric substrates to produce chromogenic reactions. From there, it can be implemented to visualize the identified active macrophages.
• In conclusion, these novel nanozymes enable one-step pathological identification of plaque vulnerability.

Imaging of Various Tumors with Nanozymes

• In order to achieve high precision and specificity in tumor detection, it is very ideal to design and manufacture simulated enzyme nanoprobes with high enzyme activity, tumor targeting and excellent luminescence performance.
• We design a novel luciferase mimic nanoprobe targeting gold nanoclusters. The nanoprobe has good stability, low cytotoxicity, high fluorescence and enzyme activity.
• The nanoprobes can effectively distinguish cancer cells from normal cells, and can be used for fluorescence / visual detection of tumor tissues.

Fig. 1 Schematic illustration of the prepared process of Au-based nanoprobes.

• Nanozymes with intrinsic enzyme-like activity have become promising approaches for cancer therapy. Ferritin is an excellent platform for size-controlled synthesis and targeted modification of nanozymes.
• We design a ferritin-based cobalt nanozyme to specifically target and visualize clinical hepatocellular carcinoma (HCC) tissues. In summary, this is a promising prognostic reagent for HCC.

Creative Enzymes provides customized nanozymes for tissue imaging, including tumor tissues and pathological tissues. We have been committed to providing our customers with nanozymes services based on brilliant technical scientists and advanced techniques to meet the needs of each customer. If you are interested in our services or have some questions, please feel free to contact us or make an online inquiry.