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Creative Enzymes has acquired a predominant market share in enzyme activity industries by the superior service quality and rigorous service attitude. We have built a specialized platform and standard protocols to assure accurate results and rapid turnover. Owning the advanced equipment and rich experiences, Creative Enzymes is able to perform suitable assays for glycoprotein-3-alpha-L-fucosyltransferase.
Glycoprotein-3-alpha-L-fucosyltransferase belongs to the hexosyltransferases, more specifically, this enzyme transfers L-fucosy group to N-linked oligosaccharide structures (N-glycans). This enzyme has specificity for N-glycans with one unsubstituted non-reducing terminal GlcNAc residue. The catalytic reaction is similar to that of glycoprotein 6-alpha-L-fucosyltransferase which also transfers L-fucosy group from GDP-beta-L-fucose, but forming alpha 1,6-linkage rather than alpha 1,3-linkage. The enzymatic reaction needs the participation of Mn2+ ion.
Glycoprotein-3-alpha-L-fucosyltransferase takes part in the various types of N-glycan biosynthesis pathways. Therefore, the products of this enzyme are widely distributed from plants to insects and some other invertebrates. This enzyme has great potentials in drug development and pharmacology. Studies have shown that the RNAi lines, generated by RNA interference technology, obtaining a targeted down-regulation FucT gene, which providing a robust tool for the production of therapeutically relevant glycoproteins in plants with a humanized N -glycan structure. As for the treatment of diseases, this enzyme is a target for the rational inhibitor design for medication in the treatment of rheumatoid arthritis. Although the crystal structure of this enzyme has not been identified yet, some modifications including mutations are already tested. The improvement in activity and stability are the two major targets. Creative Enzymes will support your research in activity measurement through accurate spectrophotometric assays.
Figure: Domain arrangements of FucT as ribbon diagrams. The C-terminal domains (CTD, right) are oriented according to structural homology, whereas the disposition of individual N-terminal domain (NTD, left) varies.
Reference: Han-YuSun et al. J Biol Chem. 2007 282(13): 9973-9982.
Creative Enzymes’ expertise is reflected in both the latest knowledge and the skillful experimental operations. Having testified by thousands of customers, the high quality of our services is well recognized in the global market. We are proud to provide enzyme assay services that meet all your research purposes. In the future, Creative Enzymes will keep on with the latest discoveries and development in enzymology and apply them to enzyme activity measurement.
