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Creative Enzymes is one of the few companies in the world that provide spectrophotometric assays for L-xylulose reductase. Its convoluted catalysis mechanism stops most companies from accurately measuring and characterizing L-xylulose reductases. With a strong team of enzymologists, Creative Enzymes is able to perform precise and fast measurement of the enzymatic activity of L-xylulose reductase. The quality of our results is assured with the most advanced spectrophotometric instruments.
L-xylulose reductase (EC 1.1.1.10, also known as xylitol dehydrogenase (ambiguous) and carbonyl reductase II) is an enzyme that catalyzes oxidation of xylitol, using NADP as the redox cofactor, to produce L-xylulose. The enzyme belongs to the superfamily of short-chain Oxidoreductases and is highly expressed in the kidney and liver of human, mouse, rat, guinea pig, and hamster. In human, L-xylulose reductase is encoded by the DCXR gene located on chromosome 17. The enzyme is highly expressed in the kidney and localizes to the cytoplasmic membrane. L-xylulose reductase catalyzes the reduction of several compounds with similar structures, including L-xylylose, pentoses, tetroses, trioses, and alpha-dicarbonyl compounds. The enzyme is involved in several biological pathways, including carbohydrate metabolism, glucose metabolism and the uronate cycle. In addition, the enzyme may also play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol. Due to its multiple functions, the enzyme is also known with other names:
Despite of its critical position in many biological processes, a widely used activity assay for L-xylulose reductase has yet been developed, which poses significant hindrances on the path of developing and utilizing the enzyme in commercial products. Fortunately, Creative Enzymes has the ability of deep method development and improved the activity assay over years. The spectrophotometric assay was demonstrated to be a reliable method for activity quantification for L-xylulose reductase. The unique service distinguishes Creative Enzymes from our competitors. Overall, Creative Enzymes is your trustworthy partner for any research and development activities involving L-xylulose reductase.
Figure: The Crystal structure of human L-xylulose reductase holoenzyme.PDB: 1PR9
