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Isocitrate Dehydrogenase (NADP+) from Yeast, Recombinant
Cat No.
NATE-0351
Description
Isocitrate dehydrogenase (IDH) (EC 1.1.1.42) is an enzyme that catalyzes the oxidative decarboxylation of Isocitrate, producing alpha-ketoglutarate (α-ketoglutarate) and CO2. This is a two-step process, which involves oxidation of Isocitrate (a secondary alcohol) to oxalosuccinate (a ketone), followed by the decarboxylation of the carboxyl group beta to the ketone, forming alpha-ketoglutarate. In humans, IDH exists in three isoforms:IDH3 catalyzes the third step of the citric acid cycle while converting NAD+ to NADH in the mitochondria. The isoforms IDH1 and IDH2 catalyze the same reaction outside the context of the citric acid cycle and use NADP+ as a cofactor instead of NAD+. They localize to the cytosol as well as the mitochondrion and peroxisome.
Abbr
IDH, Recombinant (Yeast)
Alias
IDH; IDP
Source
Pichia pastoris
Species
Yeast
Form
Liquid
Enzyme Commission Number
EC 1.1.1.42
Activity
r-ICDH activity = 100%
CAS No.
9028-48-2
Contaminants
NAD+:
Specificity
Typically >35 U/mg protein
Storage
-20°C
Synonyms
Isocitrate Dehydrogenase (NADP+); EC 1.1.1.42; IDH; Isocitrate Dehydrogenase; Dual-cofactor-specific Isocitrate dehydrogenase; IDP; Isocitrate (NADP) dehydrogenase; Isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase; Isocitrate dehydrogenase (NADP); Isocitrate dehydrogenase (NADP-dependent); NADP isocitric dehydrogenase; NADP (+)-ICDH; NADP (+)-IDH; NADP (+)-linked Isocitrate dehydrogenase; NADP-dependent Isocitrate dehydrogenase; NADP-dependent isocitric dehydrogenase; NADP-linked Isocitrate dehydrogenase; NADP-specific Isocitrate dehydrogenase; Oxalosuccinate decarboxylase; Oxalsuccinic decarboxylase; Triphosphopyridine nucleotide-linked Isocitrate dehydrogenase-oxalosuccinate carboxylase
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Download Datasheet| Catalog | Product Name | EC No. | CAS No. | Source | Price |
|---|---|---|---|---|---|
| NATE-1103 | Isocitrate dehydrogenase from Bacillus subtilis, Recombinant | EC 1.1.1.42 | 9028-48-2 | Bacillus subtilis | Inquiry |
| NATE-1649 | Mutant Isocitrate Dehydrogenase 1 R132H from Human, Recombinant | E. coli | Inquiry | ||
| NATE-0350 | Native Porcine Isocitric Dehydrogenase (NADP) | EC 1.1.1.42 | 9028-48-2 | Porcine heart | Inquiry |
| NATE-1029 | Isocitrate Dehydrogenase (NADP+) from Bacteria, Recombinant | EC 1.1.1.42 | 9028-48-2 | E. coli | Inquiry |