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Isocitrate dehydrogenase from Bacillus subtilis, Recombinant
Cat No.
NATE-1103
Description
Isocitrate dehydrogenase (IDH) (EC 1.1.1.42) and (EC 1.1.1.41) is an enzyme that catalyzes the oxidative decarboxylation of isocitrate, producing alpha-ketoglutarate (α-ketoglutarate) and CO2. This is a two-step process, which involves oxidation of isocitrate (a secondary alcohol) to oxalosuccinate (a ketone), followed by the decarboxylation of the carboxyl group beta to the ketone, forming alpha-ketoglutarate. In humans, IDH exists in three isoforms: IDH3 catalyzes the third step of the citric acid cycle while converting NAD+ to NADH in the mitochondria. The isoforms IDH1 and IDH2 catalyze the same reaction outside the context of the citric acid cycle and use NADP+ as a cofactor instead of NAD+. They localize to the cytosol as well as the mitochondrion and peroxisome.
Source
Bacillus subtilis
Form
Liquid
Enzyme Commission Number
EC 1.1.1.42
Activity
~ 13 U/mg protein
CAS No.
9028-48-2
Molecular Weight
~ 48.5kD
Unit Definition
One unit is the amount of enzyme required to convert one µmole of D-/L-isocitric acid to α-ketoglutarate per minute in Tris-HCl buffer at pH 7.6 and 25°C.
Storage
4°C
Synonyms
isocitrate dehydrogenase (NADP+); oxalosuccinate decarboxylase; oxalsuccinic decarboxylase; isocitrate (NADP) dehydrogenase; isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase; NADP-specific isocitrate dehydrogenase; NADP-linked isocitrate dehydrogenase; NADP-dependent isocitrate dehydrogenase; NADP isocitric dehydrogenase; isocitrate dehydrogenase (NADP-dependent); NADP-dependent isocitric dehydrogenase; triphosphopyridine nucleotide-linked isocitrate dehydrogenase-oxalosuccinate carboxylase; NADP+-linked isocitrate dehydrogenase; IDH (ambiguous); dual-cofactor-specific isocitrate dehydrogenase; NADP+-ICDH; NADP+-IDH; IDP; IDP1; IDP2; IDP3
Download
Download Datasheet| Catalog | Product Name | EC No. | CAS No. | Source | Price |
|---|---|---|---|---|---|
| NATE-1649 | Mutant Isocitrate Dehydrogenase 1 R132H from Human, Recombinant | E. coli | Inquiry | ||
| NATE-0350 | Native Porcine Isocitric Dehydrogenase (NADP) | EC 1.1.1.42 | 9028-48-2 | Porcine heart | Inquiry |
| NATE-0351 | Isocitrate Dehydrogenase (NADP+) from Yeast, Recombinant | EC 1.1.1.42 | 9028-48-2 | Pichia pastoris | Inquiry |
| NATE-1029 | Isocitrate Dehydrogenase (NADP+) from Bacteria, Recombinant | EC 1.1.1.42 | 9028-48-2 | E. coli | Inquiry |