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Isocitrate Dehydrogenase (NADP+) from Bacteria, Recombinant
Cat No.
NATE-1029
Description
Isocitrate dehydrogenase (IDH) (EC 1.1.1.42) is an enzyme that catalyzes the oxidative decarboxylation of Isocitrate, producing alpha-ketoglutarate (α-ketoglutarate) and CO2. This is a two-step process, which involves oxidation of Isocitrate (a secondary alcohol) to oxalosuccinate (a ketone), followed by the decarboxylation of the carboxyl group beta to the ketone, forming alpha-ketoglutarate. In humans, IDH exists in three isoforms:IDH3 catalyzes the third step of the citric acid cycle while converting NAD+ to NADH in the mitochondria. The isoforms IDH1 and IDH2 catalyze the same reaction outside the context of the citric acid cycle and use NADP+ as a cofactor instead of NAD+. They localize to the cytosol as well as the mitochondrion and peroxisome.
Abbr
IDH, Recombinant (Bacteria)
Alias
IDH
Source
E. coli
Species
Bacteria
Form
Lyophilized powder
Enzyme Commission Number
EC 1.1.1.42
Activity
> 20 U/mg protein
CAS No.
9028-48-2
Contaminants
NADPH oxidase < 0.01 % Phosphatase < 0.00015 %
Storage
Below -20°C
Synonyms
Isocitrate Dehydrogenase (NADP+); EC 1.1.1.42; IDH; Isocitrate Dehydrogenase; NADP-dependent isocitric dehydrogenase; NADP-linked Isocitrate dehydrogenase; NADP-specific Isocitrate dehydrogenase; Oxalosuccinate decarboxylase; Oxalsuccinic decarboxylase; Triphosphopyridine nucleotide-linked Isocitrate dehydrogenase-oxalosuccinate carboxylase
Download
Download Datasheet| Catalog | Product Name | EC No. | CAS No. | Source | Price |
|---|---|---|---|---|---|
| NATE-1103 | Isocitrate dehydrogenase from Bacillus subtilis, Recombinant | EC 1.1.1.42 | 9028-48-2 | Bacillus subtilis | Inquiry |
| NATE-1649 | Mutant Isocitrate Dehydrogenase 1 R132H from Human, Recombinant | E. coli | Inquiry | ||
| NATE-0350 | Native Porcine Isocitric Dehydrogenase (NADP) | EC 1.1.1.42 | 9028-48-2 | Porcine heart | Inquiry |
| NATE-0351 | Isocitrate Dehydrogenase (NADP+) from Yeast, Recombinant | EC 1.1.1.42 | 9028-48-2 | Pichia pastoris | Inquiry |