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Carboxylesterase 2 from Human, Recombinant

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Cat No.

NATE-0812

Description

Member of a serine esterase family that hydrolyze ester and amide bonds. Carboxylesterase 2 is an endoplasmic reticulum-bound hydrolase that plays a critical role in xenobiotic detoxification and activation for ester-containing therapeutics. Carboxylesterase 2 is also involved in the detoxification of drugs such as heroin and cocaine. This enzyme is thought to play a role in lipid metabolism. Human carboxylesterase 2 (hCE-2) recognizes a substrate with a large alcohol group and small acyl group. Its substrate specificity may be restricted by a capability of acyl-hCE-2 conjugate formation due to the presence of conformational interference in the active site pocket. Carboxylesterases catalyze the biotransformation of several ester-containing drugs and prodrugs such as angiotensin-converting enzyme inhibitor (temocarpil, cilazapril), anti-tumor drugs (capecitabin) and narcotics.

Abbr

CES2, Recombinant (Human)

Alias

CES2; CE-2; CES2A1; PCE-2; Ice

Source

Mouse NSO cells

Species

Human

Form

Supplied as a solution containing sodium chloride, sodium acetate, and 20% glycerol.

Enzyme Commission Number

EC 3.1.1.1

Activity

>30,000 (pmol/min/μg)

CAS No.

9016-18-6

Molecular Weight

~60 kDa

Purity

>95% (SDS-PAGE)

Concentration

0.4 - 0.6 mg/ml

Storage

Store at -70°C

Synonyms

EC 3.1.1.1; Carboxylesterase 2; CES2; CES2A1; CE-2; PCE-2; iCE

"Esterase" Total Products Page

Enzymes

Catalog	Product Name	EC No.	CAS No.	Source	Price
NATE-1916	Carboxylesterase 1 isoform c from Human, Recombinant	EC 3.1.1.1	9016-18-6	Baculovirus infected BTI insect cells	Inquiry
NATE-1915	Carboxylesterase 1 isoform b from Human, Recombinant	EC 3.1.1.1	9016-18-6	Baculovirus infected BTI insect cells	Inquiry
NATE-1633	Carboxylesterase 1D from Mouse, Recombinant			Insect cell (Baculovirus) and fused to His-tag at N-terminus	Inquiry
NATE-0229	Esterase Isoenzyme 1 from Porcine liver, Recombinant	EC 3.1.1.1	9016-18-6	E. coli	Inquiry

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