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Sialic Acid Aldolase from Escherichia coli K12, Recombinant
Cat No.
NATE-0475
Description
In enzymology, a N-acetylneuraminate lyase (EC 4.1.3.3) is an enzyme that catalyzes the chemical reaction:N-acetylneuraminate↔ N-acetyl-D-mannosamine + pyruvate. Hence, this enzyme has one substrate, N-acetylneuraminate, and two products, N-acetyl-D-mannosamine and pyruvate. This enzyme belongs to the family of lyases, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds. This enzyme participates in aminosugars metabolism.
Abbr
NALase, Recombinant (E. coli K12)
Alias
NPL; NALase; NANA lyase
Source
E. coli BL21
Species
Escherichia coli K12
Applications
Sialic acid aldolase can be used to synthesize unnatural sugars of C (6) to C (10) for the design of antagonists and inhibitors of glycoenzymes.
Product Overview
Sialic acid aldolases, or N-acetylneuraminate lyases, catalyze the reversible aldol cleavage of N-acetylneuraminic acid to form pyruvate and N-acetyl-D-mannosamine. In nature, N-acetylneuraminate lyase mainly occurs in pathogens.
Form
Lyophilized powder containing Tris-HCl and NaCl
Enzyme Commission Number
EC 4.1.3.3
Activity
> 3.0 units/mg protein
CAS No.
9027-60-5
Unit Definition
One unit will catalyze the formation of 1.0 μmol Neu-5-Ac from Man-N-Ac and pyruvate per minute at 37°C at pH 8.0.
Storage
−20°C
Synonyms
EC 4.1.3.3; Sialic Acid Aldolase; N-Acetylneuraminate lyase; N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming); N-acetylneuraminic acid aldolase; acetylneuraminate lyase; sialic aldolase; sialate lyase; N-acetylneuraminic aldolase; neuraminic aldolase; N-acetylneuraminate aldolase; neuraminic acid aldolase; N-acetylneuraminic acid aldolase; neuraminate aldolase; N-acetylneuraminic lyase; N-acetylneuraminic acid lyase; NPL; NALase; NANA lyase; acetylneuraminate pyruvate-lyase; N-acetylneuraminate pyruvate-lyase
Download
Download Datasheet| Catalog | Product Name | EC No. | CAS No. | Source | Price |
|---|---|---|---|---|---|
| NATE-1850 | N-Acetyl-D-Neuraminic Acid Aldolase (Crude Enzyme) | EC 4.1.3.3 | 9027-60-5 | E. coli | Inquiry |
| DIA-182 | Native Microorganism N-Acetylneuraminic acid aldolase | EC 4.1.3.3 | 9027-60-5 | Microorganism | Inquiry |
| NATE-0490 | Native Escherichia coli N-Acetylneuraminic Acid Aldolase | EC 4.1.3.3 | 9027-60-5 | Escherichia coli | Inquiry |
| EXWM-4908 | N-acetylneuraminate lyase | EC 4.1.3.3 | 9027-60-5 | Inquiry |