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Native Crotalus Phospholipase A2

Cat No.
NATE-0591
Description
Phospholipases A2 (PLA2s) EC 3.1.1.4 are enzymes that release fatty acids from the second carbon group of glycerol. This particular phospholipase specifically recognizes the sn-2 acyl bond of phospholipids and catalytically hydrolyzes the bond releasing arachidonic acid and lysophospholipids. Upon downstream modification by cyclooxygenases, arachidonic acid is modified into active compounds called eicosanoids. Eicosanoids include prostaglandins and leukotrienes, which are categorized as anti-inflammatory and inflammatory mediators.
Abbr
PLA2, Native (Crotalus)
Alias
PLA2
Source
Crotalus adamanteus Venom
Species
Crotalus
Product Overview
Phospholipase A2 is a member of the class of heat-stable, calcium-dependent enzymes catalyzing the hydrolysis of the 2-acyl bond of 3-n-phosphoglycerides. A chromatographically purified, dialyzed, lyophilized powder.
Form
lyophilized powder
Enzyme Commission Number
EC 3.1.1.4
Activity
> 200 units per mg dry weight
CAS No.
9001-86-9
Molecular Weight
30 kDa (Wells 1969).
Purity
chromatographically purified, dialyzed
Isoelectric point
4.55 and 4.40 for Aα and Aβ respectively (Saito 1962).
Specificity
Substrate specificity has been investigated (VanDeenen 1963).
Unit Definition
One Unit releases one micromole of acid from soybean lecithin per minute at 25°C, pH 8.9
Activators
Calcium ion (Dennis 1973).
Stability
The enzyme is stable at 90°C and pH 3.0 for at least five minutes. (Uthe 1971; Saito 1962).
Storage
Store at 2-8°C
Inhibitors
Zinc, barium, and manganese ions (Uthe 1971). Also see Golec et al. (1992).
Synonyms
EC 3.1.1.4; Phospholipases A2; PLA2s

"PLA2" Total Products Page

Catalog Product Name EC No. CAS No. Source Price
PLA2-001 Phospholipase A2 (food grade) Inquiry
NATE-0583 Native Bovine Phospholipase A2 EC 3.1.1.4 9001-84-7 Bovine pancreas Inquiry
NATE-0584 Native Crotalus durissus terrificus venom Phospholipase A2 EC 3.1.1.4 9001-84-7 Crotalus durissus terrificus venom Inquiry
NATE-0585 Native Honey bee venom (Apis mellifera) Phospholipase A2 EC 3.1.1.4 9001-84-7 Honey bee venom (Apis mellifera) Inquiry

Our Products Cannot Be Used As Medicines Directly For Personal Use.

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