Description
Neuraminidase enzymes are glycoside hydrolase enzymes (EC 3.2.1.18) that cleave the glycosidic linkages of neuraminic acids. Neuraminidase enzymes are a large family, found in a range of organisms. The best-known neuraminidase is the viral neuraminidase, a drug target for the prevention of the spread of influenza infection. The viral neuraminidases are frequently used as antigenic determinants found on the surface of the Influenza virus. Some variants of the influenza neuraminidase confer more virulence to the virus than others. Other homologs are found in mammalian cells, which have a range of functions. At least four mammalian sialidase homologs have been described in the human genome (see NEU1, NEU2, NEU3, NEU4).
Abbr
Neuraminidase, Native (Clostridium perfringens)
Source
Clostridium perfringens (C. welchii)
Applications
Neuron-specific enolase from human brain has been used in a study to assess human amniotic mesenchymal stem cells in the treatment of f ocal cerebral ischemia. It has also been used in a study to investigate sinonasal terat ocarcinosarcoma with rhabdoid features.
Product Overview
Neuron-specific enolase (NSE) is a neuronal form of the glycolytic enzyme enolase, which was first found in extracts of brain tissue.
Form
buffered aqueous solution; Solution in 100 mM Tris-HCl, 5 mM MgSO4, 250 mM KCl, pH 5.0-5.2
Enzyme Commission Number
EC 3.2.1.18
Unit Definition
One unit causes the formation of 1.0 μmole of phospho (enol)pyruvate per minute at pH 6.8 at 25°C
Pathway
Gluconeogenesis, organism-specific biosystem; Gluconeogenesis, oxaloacetate => fructose-6P, organism-specific biosystem; Gluconeogenesis, oxaloacetate => fructose-6P, conserved biosystem; Glucose metabolism, organism-specific biosystem; Glycolysis, organism-specific biosystem
Function
lyase activity; magnesium ion binding; phosphopyruvate hydratase activity
Synonyms
neuraminidase; sialidase; α-neuraminidase; acetylneuraminidase; exo-α-sialidase; EC 3.2.1.18
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