Description
Neuraminidase enzymes are glycoside hydrolase enzymes (EC 3.2.1.18) that cleave the glycosidic linkages of neuraminic acids. Neuraminidase enzymes are a large family, found in a range of organisms. The best-known neuraminidase is the viral neuraminidase, a drug target for the prevention of the spread of influenza infection. The viral neuraminidases are frequently used as antigenic determinants found on the surface of the Influenza virus. Some variants of the influenza neuraminidase confer more virulence to the virus than others. Other homologs are found in mammalian cells, which have a range of functions.
Abbr
Neuraminidase Agarose, Native (Clostridium perfringens (C. welchii))
Source
Clostridium perfringens (C. welchii)
Applications
Neuraminidase from Clostridium perfringens (C. welchii) has been used in a study to assess a glycoprotein faction suitable for use as a substrate in preparation assays. It has also been used in a study to investigate the action of an epsilion-toxin on MDCK cells.
Product Overview
Neuraminidase enzymes are hydrolase enzymes that promote influenza virus release from infected cells and facilitate virus spread.
Enzyme Commission Number
EC 3.2.1.18
Activity
Type I, 6-10 units/mg protein (using 4MU-NANA), 2-5 units/mg protein (mucin); Type II, 10-20 units/mg protein (using 4MU-NANA), 3.5-8.0 units/mg protein (mucin); Type III, > 50 units/mg protein (using 4MU-NANA).
Unit Definition
4MU-NANA Unit Definition: One unit will hydrolyze 1.0 μmole of 2'-(4-Methylumbelliferyl)-α-D-N-actetylneuraminic acid per min at pH 5.0 at 37°C.; Mucin Unit Definition: One unit will liberate 1.0 μmole of N-acetylneuraminic acid per minute at pH 5.0 at 37°C.
Synonyms
neuraminidase; sialidase; α-neuraminidase; acetylneuraminidase; exo-α-sialidase; EC 3.2.1.18; 9001-67-6
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