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arachidonate 5-lipoxygenase

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Cat No.

EXWM-0553

Description

Arachidonate 5-lipoxygenase, also known as ALOX5, 5-lipoxygenase, 5-LOX, or 5-LO, is a non-heme iron-containing enzyme (EC 1.13.11.34) that in humans is encoded by the ALOX5 gene. Arachidonate 5-lipoxygenase is a member of the lipoxygenase family of enzymes. It transforms EFA substrates into leukotrienes as well as a wide range of other biologically active products. ALOX5 is a current target for pharmaceutical intervention in a number of diseases.

Form

Liquid or lyophilized powder

Enzyme Commission Number

EC 1.13.11.34

CAS No.

80619-02-9

Storage

Store it at +4 ºC for short term. For long term storage, store it at -20 ºC～-80 ºC.

Synonyms

leukotriene-A4 synthase; Δ5-lipoxygenase; 5Δ-lipoxygenase; arachidonic 5-lipoxygenase; arachidonic acid 5-lipoxygenase; C-5-lipoxygenase; LTA synthase; leukotriene A4 synthase

Reaction

arachidonate + O2 = leukotriene A4 + H2O (overall reaction); (1a) arachidonate + O2 = (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyicosa-6,8,11,14-tetraenoate; (1b) (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyicosa-6,8,11,14-tetraenoate = leukotriene A4 + H2O

Notes

This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.

"Lipoxygenase" Total Products Page

Enzymes

Catalog	Product Name	EC No.	CAS No.	Source	Price
NATE-0407	Native Glycine max (soybean) Lipoxidase	EC 1.13.11.12	9029-60-1	Glycine max (soybean)	Inquiry
NATE-1248	15-Lipoxygenase-2 from human, Recombinant	EC 1.13.11.33		E. coli	Inquiry
NATE-1249	5-Lipoxygenase from human, Recombinant	EC 1.13.11.34	80619-02-9	S9 insect cells	Inquiry
EXWM-0532	linoleate 13S-lipoxygenase	EC 1.13.11.12	9029-60-1		Inquiry

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