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15-Lipoxygenase-2 from human, Recombinant

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Cat No.

NATE-1248

Description

Two types of 15-lipoxygenase (15-LO) have been discovered and characterized, both of which metabolize arachidonic acid (AA) to produce 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE). 15-LO-1 oxygenates AA at both C-15 and C-12, whereas 15-LO-2 exclusively oxygenates C-15 of AA. Human 15-LO-2 has a molecular mass of approximately 76 kDa and exhibits approximately 40% identity to the reticulocyte 15-LO-1. Expression of 15-LO-2 appears to be restricted to prostate, lung, skin, and cornea and may play a role in the normal development of these tissues. The protein levels and enzymatic activity of 15-LO-2 are both down-regulated in prostate cancer compared with normal and benign prostate tissues, implicating a possible protective role for 15-LO-2 against tumor formation.

Abbr

15-LOX-2, Recombinant (Human)

Alias

15-LOX-2

Source

E. coli

Species

Human

Form

PBS, pH 7.4, 1 mM DTT and 20% glycerol

Enzyme Commission Number

EC 1.13.11.33

Activity

234.15 U/ml

Molecular Weight

76 kDa

Purity

> 95% estimated by SDS-PAGE

Unit Definition

1 unit is defined as the amount of enzyme required to produce 1 nmol of 15-HpETE per min at 30°C in 50 mM Tris-HCl, pH 7.2, containing 0.003% Tween, and 250 µM arachidonic acid.

Stability

As supplied, 6 months from the QC date provided on the Certificate of Analysis, when stored properly

Storage

at -80°C

Synonyms

Arachidonate 15-lipoxygenase type II; 15-lipoxygenase-2; 15-LO-2; 15-LOX-2; ALOX15B

"Lipoxygenase" Total Products Page

Enzymes

Catalog	Product Name	EC No.	CAS No.	Source	Price
NATE-0407	Native Glycine max (soybean) Lipoxidase	EC 1.13.11.12	9029-60-1	Glycine max (soybean)	Inquiry
NATE-1249	5-Lipoxygenase from human, Recombinant	EC 1.13.11.34	80619-02-9	S9 insect cells	Inquiry
EXWM-0532	linoleate 13S-lipoxygenase	EC 1.13.11.12	9029-60-1		Inquiry
EXWM-0552	arachidonate 15-lipoxygenase	EC 1.13.11.33	82249-77-2		Inquiry

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