Our Products Cannot Be Used As Medicines Directly For Personal Use.
Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.
| Catalog | Product Name | EC No. | CAS No. | Source | Price |
|---|---|---|---|---|---|
| NATE-0503 | Native Bovine Pancreatin | 8049-47-6 | Bovine Pancreas | Inquiry | |
| NATE-0504 | Native Porcine Pancreatin | 8049-47-6 | Porcine pancrea... | Inquiry |
Pancreatin (systemic pancreatin) is a digestive enzyme supplement that contains a mixture of several different types of enzymes. These enzymes are usually produced in the pancreas. The main function of pancreatin is to help break down food and convert it into energy. The supplement consists of a commercial mixture of amylase (digesting starch), protease (digesting protein) and lipase (digesting fat).
Figure 1. Protein structure of pancreatin.
Pancreatin can be derived from plant or animal sources. The main enzymes containing pancreatin include amylase, lipase and protease. Pancreatin or pancreatin is usually made from cattle or pigs, but can also be derived from plants.
Figure 2. Pancreatic cancer.
Although some people use enzymes (such as pancreatin) for digestive problems, such as heartburn or other digestive diseases, according to Harvard Health Research, clinical research lacks evidence to support the effectiveness of digestive enzymes for indigestion and other digestive diseases.
Pancreatin is contained in pancreatin supplement capsules to help the body digest food. It is especially used to treat diseases of the digestive system with insufficiency of the pancreas (the pancreas cannot produce enough digestive enzymes, such as amylase, lipase or protease), One disease that causes pancreatic insufficiency is cystic fibrosis. In cystic fibrosis, thick mucus is released, which can block the pancreas (and other parts of the body, such as the lungs). This mucus prevents the effective secretion of pancreatic enzymes. Therefore, it has been shown in some clinical studies that taking pancreatin supplements helps to promote the effective digestion of nutrients, thereby achieving proper absorption.
It is generally believed that there are three main mechanisms for the activation of pancreatin: (1) activation of trypsinogen caused by the intestinal kinase of the duodenal mucosa; (2) autoactivation mediated by trypsinogen, trypsinogen and substrate, and false bottom to form a complex containing the trypsin inhibitor. The binding site of trypsinogen and substrate is its activation site; (3) lysosomal cysteine prolease (cysteine prolease) and entanglein B (cathepsin B) mediate trypsinogen activation. Under normal circumstances, the pancreas has a variety of protective mechanisms to protect it from damage, such as: synthesizing inactive zymogen precursors, concentrating the zymogen in the membrane-phase secretory particles, and synthesizing the trypsin inhibitor and zymogen to prevent its activation during migration and storage.
Vagus nerve has the effect of regulating pancreatic enzyme secretion. A large number of experimental data prove that indirect or direct stimulation of the vagus nerve, or the use of choline drugs, can stimulate the large release of pancreatic enzymes, and cut off the vagus nerve, causing denervated pancreas or using choline receptors to block Discontinuation can inhibit pancreatic enzyme secretion. The vagus nerve regulates pancreatic enzyme secretion, including basal secretion, cephalic secretion caused by eating, gastric secretion and intestinal secretion. Regarding the mechanism of basal pancreatic enzyme secretion, atropine can significantly reduce human basal pancreatic enzyme secretion, suggesting that vagal stress is the main factor that causes basal pancreatic enzyme secretion.
