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Urokinase from Human, recombinant

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Cat No.

NATE-1690

Description

Urokinase or Urokinase-type plasminogen activator (uPA) is a serine protease (EC 3.4.21.73). It is secreted as a single-chain zymogen, pro-Urokinase, possessing little or no intrinsic enzymatic activity. The single chain zymogen is converted into the active two chain enzyme (tcuPA) by cleavage of the bond between Lys157 and Ile158. After activation, Urokinase specifically cleaves the proenzyme plasminogen to form the active enzyme plasmin. The active plasmin then catalyzes the breakdown of fibrin polymers of blood clots. Urokinase is involved in a number of biological functions including fibrinolysis, embryogenesis, cell migration, tissue remodeling, ovulation, and wound healing. Additionally, it is a potent marker of invasion and metastasis in a variety of human cancers associated with breast, stomach, colon, bladder, ovary, brain and endometrium.

Abbr

uPA, Recombinant (Human)

Source

E. coli

Species

Human

Form

Lyophilized powder

Enzyme Commission Number

EC 3.4.21.73

Activity

>1500 mU/mg

Molecular Weight

49.3 kDa

Purity

> 90% by SDS-PAGE

Unit Definition

1 U = Digestion of 1 µmole of Z-GGR-AMC substrate in 1 min at 37ºC.

Storage

Stable at –80°C for at least 1 year as supplied. Store reconstituted aliquots at –80°C. Avoid repeated freeze and thaw cycles.

Synonyms

Two chain urokinase-type plasminogen activator; tcuPA; PLAU; ATF; UPA; URK; u-PA; BDPLT5; QPD

Reconstitution

Briefly spin down the vial and reconstitute in water to 0.5-1 mg/ml and store at –80°C.

Formulation

0.5 mg/ml solution of protein in 25 mM sodium acetate, 50 mM NaCl, pH 5.0 containing 50% glycerol.

"uPA" Total Products Page

Enzymes

Catalog	Product Name	EC No.	CAS No.	Source	Price
PHAM-262	Native Human Urokinase	EC 3.4.21.73	9039-53-6	Human urine	Inquiry
PHAM-263	Native Human Urokinase	EC 3.4.21.73	9039-53-6	Human kidney cells	Inquiry
EXWM-4165	u-plasminogen activator	EC 3.4.21.73	9039-53-6		Inquiry