Description
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit is an enzyme that in humans is encoded by the PPP1CA gene. The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Abbr
PP1A, Recombinant (Rabbit)
Package
Package size based on protein content.
Product Overview
5 kDa-15 kDa units/mg protein, recombinant, expressed in E. coli, lyophilized powder
Activity
5,000-15,000 units/mg protein
Molecular Weight
mol wt 37.5 kDa
Unit Definition
One unit will hydrolyze 1 nmole of p-nitrophenyl phosphate per min at pH 7.4 at 30°C.
Buffer
Lyophilized powder containing imidazole buffer, pH 7.4, NaCl, DTT, EDTA, MnCl2, Tween 20, and trehalose as stabilizer.
Synonyms
PPP1CA; protein phosphatase 1; PP-1A; PP1A; PP1alpha; PPP1A
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