Description
cGMP-dependent 3',5'-cyclic phosphodiesterase is an enzyme that in humans is encoded by the PDE2A gene.
Abbr
PDE2A, Recombinant (Human)
Alias
PDE2A; PDE2A1; PED2A4; cGSPDE
Source
Baculovirus infected Sf9 cells
Applications
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Product Overview
Human PDE2A (GenBank Accession No. NM_002599) amino-acids 2-941 with N-terminal FLAG-tag, MW=106 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
Molecular Weight
mol wt 106 kDa
Pathway
G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; Hemostasis, organism-specific biosystem; Morphine addiction, organism-specific biosystem; Morphine addiction, conserved biosystem; Nitric oxide stimulates guanylate cyclase, organism-specific biosystem; Platelet homeostasis, organism-specific biosystem
Function
3,5-cyclic-nucleotide phosphodiesterase activity; TPR domain binding; cAMP binding; cGMP binding; cGMP binding; cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; calcium channel activity; cyclic-nucleotide phosphodiesterase activity; drug binding; drug binding; hydrolase activity; metal ion binding; nucleotide binding; phosphoric diester hydrolase activity; protein binding; protein homodimerization activity
Synonyms
PDE2A; phosphodiesterase 2A, cGMP-stimulated; CGS-PDE; PDE2A1; PED2A4; cGSPDE
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