Description
Human PDE4A4B, also known as PDE4A isoform 1 (GenBank Accession No. NM_001111307) amino acids 2-end with N-terminal GST-tag, MW= 124 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
Abbr
PDE4A, Recombinant (Human)
Source
Baculovirus infected Sf9 cells
Applications
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Product Overview
Human PDE4A4B, also known as PDE4A isoform 1 (GenBank Accession No. NM_001111307) amino acids 2-end with N-terminal GST-tag, MW= 124 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
Molecular Weight
mol wt 124 kDa
Unit Definition
One unit is defined as the amount of enzyme that will convert 1 pmole of 3?, 5?-cAMP to 5?-AMP per min at 37°C.
Pathway
DARPP-32 events, organism-specific biosystem; G Protein Signaling Pathways, organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; Morphine addiction, organism-specific biosystem; Morphine addiction, conserved biosystem; Myometrial Relaxation and Contraction Pathways, organism-specific biosystem
Function
3,5-cyclic-AMP phosphodiesterase activity; 3,5-cyclic-nucleotide phosphodiesterase activity; cAMP binding; drug binding; hydrolase activity; metal ion binding; phosphoric diester hydrolase activity
Synonyms
DPDE2; PDE46; phosphodiesterase 4A, cAMP-specific; PDE4A10; PDE4A
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