Description
Staphopains A and B are part of the staphylococcal proteolytic cascade (SPC) and may contribute to tissue invasion and metastatic infections of Staphylococcus aureus. Staphopain A, along with Staphopain B, may contribute to septic shock through the release of bradykinin and S-kinin from human kininogens. This activity required proteolytically-active Staphopain A and was augmented by Staphopain B.
Abbr
sspB, Native (Staphylococcus aureus)
Source
Staphylococcus aureus
Product Overview
Staphopain activity is inhbited by staphostatin B (sspC) and E-64. Staphopain activity is stimulated by EDTA.. Staphopain A and Staphopain B, members of the peptidase C47 family, are the major cysteine proteases secreted by S. aureus.
Enzyme Commission Number
EC 3.4.22.48
Molecular Weight
mol wt ~20 kDa by SDS-PAGE
Warnings
Lyophilized from a solution containing 25 mM sodium acetate pH 5.5, 100 mM NaCl, and 0.5 mM EDTA. Each vial contains 0.1 mg of protein. Reconstitute with 0.2 mLs of water to create a 0.5 mg/mL solution.
Synonyms
Staphopain; EC 3.4.22.48; staphylopain; 347841-89-8; Staphopain B; Staphylococcal cysteine proteinase B; Staphylopain B; sspB
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