Description
Myeloperoxidase (MPO) is a peroxidase enzyme that in humans is encoded by the MPO gene on chromosome 17. MPO is most abundantly expressed in neutrophil granulocytes (a subtype of white blood cells), and produces hypohalous acids to carry out their antimicrobial activity. It is a lysosomal protein stored in azurophilic granules of the neutrophil and released into the extracellular space during degranulation. MPO has a heme pigment, which causes its green color in secretions rich in neutrophils, such as pus and some forms of mucus.
Abbr
MPOC, Native (Human)
Applications
Protein Cystalline Research
Enzyme Commission Number
EC 1.11.1.7
Activity
Typically > 1 ,000 U/mg protein
Unit Definition
One unit of Myeloperoxidase will catalyze the consumption of one micromole of hydrogen peroxide and the production of 1/4 micromole of tetraguaiacol per minute at pH 7.0 and 25°C.
Pathway
C-MYB transcription factor network, organism-specific biosystem; Folate Metabolism, organism-specific biosystem; IL23-mediated signaling events, organism-specific biosystem; Phagosome, organism-specific biosystem; Phagosome, conserved biosystem; Selenium Pathway, organism-specific biosystem; Transcriptional misregulation in cancer, organism-specific biosystem
Function
chromatin binding; heme binding; heparin binding; metal ion binding; oxidoreductase activity; peroxidase activity
Synonyms
MPOC; MPO C; Myeloperoxidase Isoform C; EC 1.11.1.7; 9003-99-0
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