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Native Human Dipeptidyl Peptidase-4

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Cat No.

NATE-0962

Description

Native DPPIV is a ubiquitous type II transmembrane glycoprotein and a serine protease of the S9 prolyl-oligopeptidase family. In vivo, it is synthesized with a signal peptide, which functions as the membrane anchoring domain. There is an 88% sequence homology between the human and porcine kidney enzymes. Both exist as homodimers with a subunit molecular weight of ~30 kDa. The high mannose 100 kDa DPPIV precursor is processed in the Golgi to yield a 124 kDa heavily N-and O-linked mature glycoprotein. It is then sorted to the apical membrane through the concerted action of both N-and O-linked glycans and its association with lipid microdomains. The porcine enzyme contains 18.3% carbohydrates, which the glycan composition is 0.9% fucose, 3.4% mannose, 5.1% galactose, 8.2% glucosamine, and 0.7% sialic acid. DPPIV is highly expressed on endothelial cells, epithelial cells, and lymphocytes. It is also present in plasma in its soluble form.

Abbr

DPP4, Native (Human)

Alias

DPP4; DPPIV; CD26

Source

Human Placenta

Species

Human

Applications

Diagnostic Controls, Calibrators & Standards; Clinical Chemistry; Testing/Assay Validation; Life Science; ELISA; Blotting; Manufacturing

Form

Liquid

Enzyme Commission Number

EC 3.4.14.5

Purity

> 95% (SDS-PAGE)

Unit Definition

One unit is defined as the amount of enzyme that hydrolyzes one umole of H-Gly-Pro-pNA per minute at 25°C, pH 7.8

Stability

2 years

Storage

Store at -20°C

Synonyms

Adenosine Deaminase Complexing Protein 2; CD26; DPP4

"DPP IV" Total Products Page

Enzymes

Catalog	Product Name	EC No.	CAS No.	Source	Price
NATE-0203	Native Porcine Dipeptidyl Peptidase IV	EC 3.4.14.5	54249-88-6	Porcine Kidney	Inquiry
NATE-0204	Dipeptidyl Peptidase IV from Human, Recombinant	EC 3.4.14.5	54249-88-6	Baculovirus infected Sf9 cells	Inquiry
EXWM-4050	dipeptidyl-peptidase IV	EC 3.4.14.5	54249-88-6		Inquiry