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Native Glutamine Synthetase from Microorganism

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Cat No.

DIA-411

Description

Glutamine synthetase (GS) (EC 6.3.1.2) is an enzyme that plays an essential role in the metabolism of nitrogen by catalyzing the condensation of glutamate and ammonia to form glutamine: Glutamate + ATP + NH3 → Glutamine + ADP + phosphate. Glutamine Synthetase uses ammonia produced by nitrate reduction, amino acid degradation, and photorespiration. The amide group of glutamate is a nitrogen source for the synthesis of glutamine pathway metabolites.

Abbr

GS, Native (Microorganism)

Alias

Source

Microorganism

Appearance

Light yellow lyophilizate

Enzyme Commission Number

EC 6.3.1.2

Activity

> 7 U/mg lyophilizate

CAS No.

9023-70-5

Contaminants

catalase < 0.5%

Molecular Weight

ca. 900 kDa

Isoelectric point

6.5

pH Stability

6.5–9.5

Michaelis Constant

1.5 x 10^-2 M (L-glutamate) 1.3 x 10^-4 M (ammonia) 8.7 x 10^-4 M (ATP)

Structure

57 kDa (SDS-PAGE)

Specificity

L-glutamate (100), D-glutamate (0.8), NH3 (100), NH2OH (12), ATP (100), GTP (2.5)

Unit Definition

One unit (U) is defined as the amount of enzyme which produces 1 μmol of phosphate per min at 37°C and pH 7.0.

Optimum pH

Optimum temperature

60°C

Activators

Mg2+, Mn2+

Thermal stability

below 40°C

Storage

at -20°C

Stabilizers

Sucrose

Inhibitors

methionine sulfoximine, carbamyl phosphate

Synonyms

Glutamine synthetase; GS; EC 6.3.1.2; Glutamate-ammonia ligase

"GS" Total Products Page

Enzymes

Catalog	Product Name	EC No.	CAS No.	Source	Price
NATE-1675	Glutamine Synthetase from Human, recombinant	EC 6.3.1.2	9023-70-5	E. coli	Inquiry
DIA-155	Native Bacillus sp. Glutamine synthetase	EC 6.3.1.2	9023-70-5	Bacillus sp.	Inquiry
NATE-0321	Native Escherichia coli L-Glutamine Synthetase	EC 6.3.1.2	9023-70-5	Escherichia coli	Inquiry
EXWM-5722	glutamine synthetase	EC 6.3.1.2	9023-70-5		Inquiry

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