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microbial collagenase
Cat No.
EXWM-4311
Description
Six species of metalloendopeptidase acting on native collagen can be isolated from the medium of Clostridium histolyticum. Class I has forms α (68 kDa), β (115 kDa) and γ (79 kDa); class II has Δ (100 kDa), ε (110 kDa) and ζ (125 kDa). The two classes are immunologically crossreactive, but have significantly different sequences, and different specificities such that their actions on collagen are complementary. The enzymes also act as peptidyl-tripeptidases. Variants of the enzyme have been purified from Bacillus cereus, Empedobacter collagenolyticum, Pseudomonas marinoglutinosa, and species of Vibrio, Vibrio B-30 (ATCC 21250) and V. alginolyticus (previously Achromobacter iophagus). Also known from Streptomyces sp.. The Vibrio enzyme is the type example of peptidase family M9.
Form
Liquid or lyophilized powder
Enzyme Commission Number
EC 3.4.24.3
CAS No.
9001-12-1
Storage
Store it at +4 ºC for short term. For long term storage, store it at -20 ºC～-80 ºC.
Synonyms
Clostridium histolyticum collagenase; clostridiopeptidase A; collagenase A; collagenase I; Achromobacter iophagus collagenase; collagenase; aspergillopeptidase C; nucleolysin; azocollase; metallocollagenase; soycollagestin; Clostridium histolyticum proteinase A; clostridiopeptidase II; MMP-8; clostridiopeptidase I; collagen peptidase; collagen protease; collagenase MMP-1; metalloproteinase-1; kollaza; matrix metalloproteinase-1; MMP-1; matrix metalloproteinase-8; matirx metalloproteinase-18; interstitial collagenase
Reaction
Digestion of native collagen in the triple helical region at ┼Gly bonds. With synthetic peptides, a preference is shown for Gly at P3 and P1', Pro and Ala at P2 and P2', and hydroxyproline, Ala or Arg at P3'
Notes
This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
Download
Download Datasheet"Collagenase" Total Products Page
| Catalog | Product Name | EC No. | CAS No. | Source | Price |
|---|---|---|---|---|---|
| NATE-1917 | Collagenase/Neutral Protease Blend (GMP Grade) | Clostridium histolyticum/Bacillus polymyxa | Inquiry | ||
| DIGS-253 | Native Clostridium histolyticum Collagenase | EC 3.4.24.3 | 9001-12-1 | Clostridium histolyticum | Inquiry |
| NATE-1594 | Collagenase (food grade) | Inquiry |