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Matrix Metalloproteinase-3 from Human, Recombinant

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Cat No.

NATE-0861

Description

Matrix metalloproteinase-3 (MMP-3) also known as stromelysin-1 and transin (EC 3.4.24.17) cleaves a number of substrates including cartilage proteoglycan, collagen types II, III, IV, V and IX, fibronectin, laminin, and can activate MMP 1. MMP-3 is secreted as 57 and 59 kDa proenzymes and can be activated in vitro by organomercurials (e.g., 4 aminophenylmercuric acetate, APMA) and in vivo by proteases via intermediate forms to a 45 kDa active MMP 3 enzyme. Further autolysis to a 28 kDa form can also occur. MMP-3 is thought to play an important role in pathophysiological degradation processes associated with conditions such as rheumatoid arthritis and cancer cell invasion.

Abbr

MMP-3, Recombinant (Human)

Alias

MMP-3

Species

Human

Applications

Immunoblotting; Substrate Cleavage Assay; Zymography

Product Overview

Recombinant, human pro-MMP-3 purified from cell culture supernatant. May be used as a positive control or standard for zymographic analysis, or substrate assay. Requires activation for immunoblotting, prior to use. M.W. 57000/58000.

Form

Lyophilized from 100 mM NaCl, 50 mM HEPES, pH 7.3.

Enzyme Commission Number

EC 3.4.24.17

CAS No.

79955-99-0

Molecular Weight

57 kDa

Purity

>95% by SDS-PAGE

Storage

< -70°C; Avoid freeze/thaw

Synonyms

Stromelysin 1; EC 3.4.24.17; matrix metalloproteinase 3; proteoglycanase; collagenase activating protein; procollagenase activator; transin; MMP-3; neutral proteoglycanase; stromelysin; collagen-activating protein

"Matrix Metalloproteinase" Total Products Page

Enzymes

Catalog	Product Name	EC No.	CAS No.	Source	Price
NATE-0451	Matrix Metalloproteinase-7 from human, Recombinant		141256-52-2	E. coli	Inquiry
NATE-0858	Matrix Metalloproteinase-1 from Human, Recombinant	EC 3.4.24.7	2593923	Human Rheumatoid Synovial Fibroblast	Inquiry
NATE-0859	Matrix Metalloproteinase-13 (His•Tag) from Human, Recombinant			S. frugiperda	Inquiry
NATE-0860	Matrix Metalloproteinase-2 from Human, Recombinant	EC 3.4.24.24	146480-35-5	CHO Cells	Inquiry

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