Description
Type II is the predominant IMPDH isoform and is specifically linked to a wide range of cancers and lymphocyte proliferation.
Abbr
IMPDH2, Recombinant (Human)
Alias
IMPDH II; IMPDH2; IMPD 2
Package
vial of > 0.002 unit
Form
Solution in 20 mM Tris-HCl, pH 8.0, containing 0.5 mM EDTA and 1 mM DTT.
Enzyme Commission Number
EC 1.1.1.205
Unit Definition
One unit will produce 1.0 μ mole of XMP from IMP with corresponding reduction of β-NAD per minute at pH 8.0 at 25°C.
Pathway
Drug metabolism-other enzymes, organism-specific biosystem; Drug metabolism-other enzymes, conserved biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of nucleotides, organism-specific biosystem; Purine metabolism, organism-specific biosystem; Purine metabolism, organism-specific biosystem
Function
DNA binding; IMP dehydrogenase activity; RNA binding; metal ion binding; nucleotide binding; oxidoreductase activity
Synonyms
inosine-5'-phosphate dehydrogenase; inosinic acid dehydrogenase; inosinate dehydrogenase; inosine 5'-monophosphate dehydrogenase; inosine monophosphate dehydrogenase; IMP oxidoreductase; inosine monophosphate oxidoreductase; IMP dehydrogenase; IMP:NAD+ oxidoreductase; EC 1.1.1.205; IMPDH II; IMPDH2; IMPD 2
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