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Cathepsin D from Human, recombinant

Cat No.
NATE-1707
Description
Cathepsin D is a lysosomal aspartyl protease composed of a protein dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is an estrogen-regulated protein associated with tissue breakdown. Levels of cathepsin D have been positively correlated with recurring breast cancers of both node negative and node positive types. Additionally cathepsin D has been associated with amyloid formation in Alzheimer's plaques. Cathepsin D is produced initially as a pre-pro-enzyme which gets transported to lysosomes via endosomes in most cell types. In endosomes, it gets proteolyzed by unidentified proteases by removal of the pro-peptide to generate active single-chain Cathepsin D; while in lysosomes, further processing by cysteine cathepsins B and L generates mature, active double-chain Cathepsin D.
Abbr
CTSD, Recombinant (Human)
Source
E. coli
Species
Human
Form
Freeze-Dried
Enzyme Commission Number
EC 3.4.23.5
Activity
>100 pmol/min/mg
CAS No.
9025-26-7
Molecular Weight
45.1 kDa
Purity
> 80% by SDS-PAGE
Storage
Store at -20°C. Stable for at least 6 months as supplied. Reconstitute to 1 mg/ml in sterile water, store at –80°C in aliquots and use within 6 months after reconstitution. Avoid repeated freeze-thaw cycles.
Synonyms
CTSD; 9025-26-7; EC 3.4.23.5; CLN10; CPSD; HEL-S-130P; Procathepsin D
Reconstitution
Reconstitute to 1 mg/ml in water.
Reaction
ATP + nucleoside monophosphate = ADP + nucleoside diphosphate
Notes
Many nucleotides can act as acceptor; other nucleoside triphosphates can act instead of ATP. Requires Mg2+.

"CTSD" Total Products Page

Catalog Product Name EC No. CAS No. Source Price
NATE-1874 Native Human Cathepsin D EC 3.4.23.5 9025-26-7 Human Spleen Inquiry
NATE-0171 Native Bovine Cathepsin D EC 3.4.23.5 9025-26-7 Bovine spleen Inquiry
NATE-0172 Native Human Cathepsin D EC 3.4.23.5 9025-26-7 Human liver Inquiry
EXWM-4287 cathepsin D EC 3.4.23.5 9025-26-7 Inquiry

Our Products Cannot Be Used As Medicines Directly For Personal Use.

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