events
Mark your calendar for November 19-21 and meet us at Fi Europe 2024, Messe Frankfurt, Germany. We look forward to connecting with you at this exciting event!
Learn More >>
Products

Enzymes for Research, Diagnostic and Industrial Use

Products
Online Inquiry

Our Products Cannot Be Used As Medicines Directly For Personal Use.

24 hour
Promise

Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.

Cathepsin D from Human, recombinant

Cat No.
NATE-1707
Description
Cathepsin D is a lysosomal aspartyl protease composed of a protein dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is an estrogen-regulated protein associated with tissue breakdown. Levels of cathepsin D have been positively correlated with recurring breast cancers of both node negative and node positive types. Additionally cathepsin D has been associated with amyloid formation in Alzheimer's plaques. Cathepsin D is produced initially as a pre-pro-enzyme which gets transported to lysosomes via endosomes in most cell types. In endosomes, it gets proteolyzed by unidentified proteases by removal of the pro-peptide to generate active single-chain Cathepsin D; while in lysosomes, further processing by cysteine cathepsins B and L generates mature, active double-chain Cathepsin D.
Abbr
CTSD, Recombinant (Human)
Source
E. coli
Species
Human
Form
Freeze-Dried
Enzyme Commission Number
EC 3.4.23.5
Activity
>100 pmol/min/mg
CAS No.
9025-26-7
Molecular Weight
45.1 kDa
Purity
> 80% by SDS-PAGE
Storage
Store at -20°C. Stable for at least 6 months as supplied. Reconstitute to 1 mg/ml in sterile water, store at –80°C in aliquots and use within 6 months after reconstitution. Avoid repeated freeze-thaw cycles.
Synonyms
CTSD; 9025-26-7; EC 3.4.23.5; CLN10; CPSD; HEL-S-130P; Procathepsin D
Reconstitution
Reconstitute to 1 mg/ml in water.
Reaction
ATP + nucleoside monophosphate = ADP + nucleoside diphosphate
Notes
Many nucleotides can act as acceptor; other nucleoside triphosphates can act instead of ATP. Requires Mg2+.

"CTSD" Total Products Page

Catalog Product Name EC No. CAS No. Source Price
NATE-1874 Native Human Cathepsin D EC 3.4.23.5 9025-26-7 Human Spleen Inquiry
NATE-0171 Native Bovine Cathepsin D EC 3.4.23.5 9025-26-7 Bovine spleen Inquiry
NATE-0172 Native Human Cathepsin D EC 3.4.23.5 9025-26-7 Human liver Inquiry
EXWM-4287 cathepsin D EC 3.4.23.5 9025-26-7 Inquiry

Our Products Cannot Be Used As Medicines Directly For Personal Use.

0
Click unfold / close
Inquiry Basket
Delete selected Quote Check Out
Decide to move out of the shopping cart?
Sure No, Back

Please choose product!

< Go Back
You have already added to buy this product