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Aflatoxin B1 aldehyde reductase member 2 from Human, Recombinant
Cat No.
NATE-1196
Description
Aflatoxin B1 aldehyde reductase member 2 catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.
Abbr
AKR7A2, Recombinant (Human)
Alias
AKR7A2
Source
Human
Enzyme Commission Number
EC 1.1.1.n11
Molecular Weight
39588.9 Da
Synonyms
AFB1 aldehyde reductase 1; AFB1-AR 1; Aldoketoreductase 7; Succinic semialdehyde reductase
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