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Carboxypeptidase-B from rat, Recombinant
Cat No.
NATE-0993
Description
Carboxypeptidase B, recombinant, is intended to use in highly regulated production processes at pharmaceutical companies. Carboxypeptidase B is a widely used metalloprotease, typically isolated from pancreas of different animals, that specifically releases arginine and lysine from the C-terminus of peptides and proteins. Roche has chemically synthesized a gene encoding for the amino acid sequence of the rat Carboxypeptidase B and has transformed the gene into the expression host Pichia pastoris, which expresses the recombinant Carboxypeptidase B as active protease with identical properties compared to the native Carboxypeptidase B. The product is manufactured according to DIN EN ISO 13485. No animal-derived products are used in the fermentation, purification and final formulation. The production process is validated resulting in a very high lot-to-lot consistency. Eliminate the risk of virus contamination and the risk of animal-related cross-contamination. Rely on high purity. Minimize the risk of host cell protein contamination in your final product. Increase the safety of your production processes with robust and reproducible performance and high lot-to-lot consistency.
Abbr
CPB1, Recombinant (Rat)
Alias
CPB1
Source
Pichia pastoris
Species
Rat pancreas
Applications
Use the animal component-free and DIN EN ISO 13485-manufactured Carboxypeptidase B, recombinant, as critical raw material for the production of active pharmaceutical ingredients (API), i.e., insulin.
Appearance
Clear, colorless to slightly yellowish solution
Activity
>210 U/mg
Purity
>85%
Concentration
>400 U/ml
Stability
At -15 to -25°C within specification range for 24 months.
Storage
Tris/HCl, 33 mmol/l; ZnCl2, 0.1 mmol/l; pH 7.5-8.5 at +25°C
Synonyms
protaminase; pancreatic carboxypeptidase B; tissue carboxypeptidase B; peptidyl-L-lysine [L-arginine] hydrolase
Download
Download Datasheet| Catalog | Product Name | EC No. | CAS No. | Source | Price |
|---|---|---|---|---|---|
| NATE-0151 | Native Human Carboxypeptidase B | EC 3.4.17.2 | 9025-24-5 | Human pancreas | Inquiry |
| NATE-0152 | Native Porcine Carboxypeptidase B | EC 3.4.17.2 | 9025-24-5 | Porcine pancreas | Inquiry |
| NATE-0153 | Carboxypeptidase-B rat, Recombinant | EC 3.4.17.2 | 9025-24-5 | E. coli | Inquiry |
| NATE-1147 | Carboxypeptidase B from Porcine, Recombinant | EC 3.4.17.2 | Porcine | Inquiry |