events
Mark your calendar for November 19-21 and meet us at Fi Europe 2024, Messe Frankfurt, Germany. We look forward to connecting with you at this exciting event!
Learn More >>
Products

Enzymes for Research, Diagnostic and Industrial Use

Products
Online Inquiry

Our Products Cannot Be Used As Medicines Directly For Personal Use.

24 hour
Promise

Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.

Poly [ADP-ribose] polymerase 1

Official Full Name
Poly [ADP-ribose] polymerase 1
Background
PARP-1, a nuclear enzyme that synthesizes ADP-ribose polymers from NAD, specifically binds Zn2+ and DNA, and recognizes single-strand breaks in DNA. It is involved in base excision repair, both short-patch and long-patch, rejoining DNA strand breaks and plays a role in p53 expression and activation. A high level of basal neuronal DNA damage and PARP activity has been reported in rat brain tissue. PARP-1 was shown to be required for HIV-1 integration into DNA. If PARP-1 is deficient there is no productive HIV-1 infection.
Synonyms
PARP1; poly (ADP-ribose) synthase; ADP-ribosyltransferase (polymerizing); NAD ADP-ribosyltransferase; PARP; PARP-1; NAD+:poly (adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase (incorrect); NAD+:poly (adenosine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase; EC 2.4.2.30
Catalog Product Name EC No. CAS No. Source Price
EXWM-2658 NAD+ ADP-ribosyltransferase EC 2.4.2.30 58319-92-9 Inquiry
NATE-0507 Poly [ADP-ribose] polymerase 1 from Human, Recombinant EC 2.4.2.30 58319-92-9 E. coli Inquiry