Enzymes for Research, Diagnostic and Industrial Use
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Catalog | Product Name | EC No. | CAS No. | Source | Price |
---|---|---|---|---|---|
EXWM-2440 | hyaluronan synthase | EC 2.4.1.212 | 39346-43-5 | Inquiry | |
NATE-1485 | Hyaluronan synthase from Pasteurella multocida, Recombinant | EC 2.4.1.212 | 39346-43-5 | E. coli | Inquiry |
Hyaluronic acid synthase (HAS) is a type of enzyme that exists on the plasma membrane and can specifically act in the process of hyaluronic acid (HA) synthesis. In 1993, DeAngelis successfully cloned the first HAS from group A streptococci by using transposon mutation method, named spHAS (S.pyogenesHAS), which opened the prelude to human research expressing HAS from different sources and different functions. In 1996, 4 laboratories in the United States almost simultaneously confirmed the HAS-cDNAs of eukaryotes, confirming that the human HAS gene is a multi-gene family, which encodes 3 isoenzymes: HAS1, HAS2 and HAS3. The phased research of eukaryotic HAS has greatly promoted the biosynthesis of HA. Now, in some mammalian cells and some eukaryotic cells, the synthesis of HA through a single HAS protein has become a reality. Currently, HA is a product of HAS catalyzed synthesis, and its preparations have been widely used in clinical practice. However, the enzyme HAS, which plays a key role in the synthesis of human HA, has just entered a new stage of research and application in both its biological function and clinical application.
Figure 1. Protein structure of hyaluronic acid synthase.
The expression of HAS at different developmental stages. Scientists have studied the expression of HAS in different developmental stages of human body by using naturally occurring mutation method, transgenic technology and gene knockout technology, and found that different HAS play different roles in the process of HA synthesis. HAS1 is expressed throughout the life process. Although the level of high molecular weight HA catalyzed by it is very low in various cells, it is essential to maintain the normal function of the body. HAS2 is significantly expressed in the embryonic development stage. The high molecular weight HA catalyzed by it has an important role in maintaining tissue structure and body fluid balance, which is of great significance in the expansion and growth of body tissue. HAS3 is expressed in many tissues in the late embryo and adult. It can be used in the surrounding matrix of the cell spontaneously, and it can bind to the HA receptor on the cell surface to stimulate a signal cascade and produce a variety of intracellular physiological effects.
The application of HA in the field of pharmacy is in the ascendant. As the key enzyme for the synthesis of HA, HAS has attracted widespread attention.
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