Serrapeptase

Serrapeptase

Serrapeptase is a powerful proteolytic enzyme. Compared with trypsin and chymotrypsin, the enzymolysis is stronger, and it is used clinically to reduce phlegm and increase antibiotic action. It is a neutral protease, extracted from Bacillus subtilis by fermentation. It belongs to an endonuclease and can be used for various protein hydrolysis treatments. Under certain temperature and PH value, this product can hydrolyze macromolecular protein into amino acid and other products. It can be widely used in the hydrolysis of animal and plant proteins to produce HAP and HVP that produce high-quality seasonings and food nutrition enhancers. In addition, it can also be used in the processing of leather depilation, softening, and degumming of wool and silk.

Figure 1. Protein structure of serrapeptase.

Functions

• Reduce Inflammation

Serrapeptase is most commonly used to reduce inflammation-the body's response to injury. In the field of dentistry, the enzyme has been used in smaller surgical procedures, such as removing teeth to relieve pain, jaw and facial swelling. Serrapeptase is thought to reduce inflammatory cells in the affected area. The researchers concluded that salad peptidase is more effective than ibuprofen and corticosteroids in improving the symptoms of inflammation. Although ibuprofen and corticosteroids can suppress inflammation, corticosteroids reduce facial swelling the next day performance is better than salad peptidase, but the difference between the two is not obvious. Nonetheless, due to the lack of qualified research, no analysis of pain is possible. In the same study, the researchers also concluded that serrapeptase is safer than other drugs used in the analysis-implying that it can be substituted if it is intolerant to other drugs or has adverse side effects.

• Prevent infection

Serrapeptase can reduce the risk of bacterial infections. In so-called biofilms, bacteria can gather together to form a protective barrier around them. This biofilm can act as a protective layer for antibiotics, allowing bacteria to grow rapidly and cause infections. Serrapeptase inhibits the formation of biofilms, thereby increasing the effectiveness of antibiotics. Studies have shown that serrapeptase can increase the efficiency of antibiotics in the treatment of Staphylococcus aureus (Staphylococcus aureus), which is the main cause of healthcare-related infections.

• May be useful for chronic respiratory diseases

Serrapeptase can increase mucus clearance in people with chronic respiratory disease (CRD) and reduce lung inflammation. CRD is a disease of the airways and other structures of the lungs. Common diseases include chronic obstructive pulmonary disease (COPD), asthma, and pulmonary hypertension-a type of high blood pressure that affects the blood vessels in your lungs. Although CRD cannot be cured, various treatments can help dilate air passages or increase mucus clearance, thereby improving quality of life. In a four-week study, 29 people with chronic bronchitis were randomly assigned to receive 30 mg serrapeptase or placebo daily. Bronchitis is a type of COPD that causes coughing and difficulty breathing due to excessive mucus. Compared with the placebo group, those receiving serrapeptase treatment produced less mucus and were able to clear the mucus in the lungs better. However, further research is needed to support these findings.

Applications

• Production of animal and vegetable protein hydrolyzed powder (HAP, HVP)

The enzymatic reaction of neutral protease can hydrolyze the macromolecular proteins of animals and plants into small molecular peptides or amino acids to facilitate the effective absorption and utilization of the protein. The hydrolysate has high AN%, high degree of hydrolysis, and good flavor. Used in the production of advanced seasonings and food nutrition enhancers, various animal-derived extracts to produce functional bones, meat extracts (ostein), aquatic extracts, peptones, peptides, etc. and research and development of some high value-added functions food.

• Baking industry

Neutral protease can hydrolyze dough proteins into peptones, peptides and even amino acids, thereby weakening dough gluten strength, making it have good plasticity and extensibility, and maintaining clear and beautiful printing patterns. Improve the gloss of the finished product, make the cross-section of the biscuit clear, the structure is uniform, the taste is crisp and crisp.

• Soy protein isolate

It can hydrolyze soy protein isolate into small molecular peptides, which greatly improves the biological potency of soy protein isolate, making it easy for human body to digest and absorb. It also improves the dissolution, reduces the viscosity, and improves the functional characteristics of soy protein isolate.

• Production of yeast extract and yeast extract

Improve the protein utilization and flavor of the final product.

• Beer industry

Adding neutral protease to decompose protein into peptides and free amino nitrogen, especially for barley, soybean and other vegetable protein, has obvious effect. It is used in beer production to eliminate the "cold turbidity" phenomenon caused by protein.

• Pharmaceutical industry

Drugs containing neutral proteases can have anti-inflammatory, choleretic, analgesic, and digestive effects.

Reference

1. Nakahama K, et al. Cloning and sequencing of Serratia protease gene. Nucleic Acids Res. 1986, 14 (14): 5843–55.