CDK15 kinases belongs to TAIRE subfamily. Breast Cancer (BC) is one of the most common malignancies in women worldwide. There are many subtypes of breast cancer, and different treatment methods are adopted based on the characteristics of each subtype. Although there are effective methods to treat breast cancer such as surgery, chemotherapy and radiation therapy, once the breast cancer has metastasized, it will endanger the patient's life. Therefore, it is important to further explore the molecular mechanism of breast cancer metastasis and find new strategies to reduce the mortality of breast cancer patients. CDKs (Cyclin-dependent kinases) are a classic serine/threonine protein kinase family. Current research shows that CDKs are mostly oncogenes that play an important role in cell cycle regulation and transcription. CDK15 is a member of the cell cycle-dependent kinase family, which is located on chromosome 2q33.1 and has homology with the CDK14 gene; however, there is no clear report on the role of CDK15 in various tumors. We know little about the genesis and development of breast cancer and related molecular mechanisms.
In recent years, with the increase of CDKs-related research, more and more functions are well known: CDK7 expression can maintain the transcription of important gene clusters in triple-negative breast cancer. Due to the special dependence of this gene cluster on CDK7, CDK7-specific inhibitor THZ1 can covalently bind CDK7 to modify its cysteine residues and cause long-term irreversible inactivation of CDK7. The effective inhibition of CDK7 may be a reasonable method for treating triple-negative breast cancer and non-small cell lung cancer. CDK10 Both M-shaped G-complex and Cyclin can increase the stability of each other and play a positive role in the regulation of the cell cycle. It can also play a role in suppressing cancer in some tumors, such as CDK10 as a tumor suppressor gene to inhibit bile duct cancer cells. Proliferation and migration; ubiquitination of CDK10 in breast cancer leads to down-regulation of its protein expression, which is responsible for resistance to endocrine therapy; and CDK10 low expression in hepatocellular carcinoma promotes cell proliferation and migration and is positively correlated with low overall survival of patients. In addition to being involved in splicing and transcription of the precursor mRNA after phosphorylation activation, 76LCD11 is also a key regulator of autophagy, and its deletion will cause the accumulation of autophagy intermediates, thereby inhibiting the process. There are still many unsolved mysteries in the CDKs family. Whether CDKs have broader molecular mechanisms in tumorigenesis and development requires further investigation. Cyclin-dependent kinase 15 is the 15th member of the CDKs family. The CDK15 gene is located on chromosome 2q33.1, and has high homology with CDK14.
