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Y-27632
Cat No.
CEI-1586
Description
Y-27632 2HCl is a selective inhibitor of ROCK1 (p160ROCK) with a Ki value of 140 nM.
Product Overview
Y-27632 is a specific inhibitor of Rho-associated kinases(ROCK) family with Ki values of 0.22μM and 0.30μM for ROCK1 and ROCK2, respectively. Y-27632 has shown selectivity of inhibition by comparing their Ki values for other Rho effector kinases, citron kinase and PKN, as well as PKCα. The Ki values of Y-27632 for citron kinase and PKN are least 20-fold higher, and Ki values for PKCα are about 200-fold higher than those for ROCK kinases. In addition, Y-27632 has been reported to inhibit ROCK1 and ROCK2 by competing with ATP for binding to the kinase in HeLa cells. Besides, Y-27632 has also shown the inhibition of stress fibers in Swiss 3T3 cells when the concentration of Y-27632 is 10μM.
CAS No.
146986-50-7
Molecular Weight
247.34
Purity
0.98
Storage
Store at-20°C
Targets
ROCK
IC50
140 nM(Ki); 300 nM(Ki)
Molecular Formula
C14H21N3O
Chemical Name
4-[(1R)-1-aminoethyl]-N-pyridin-4-ylcyclohexane-1-carboxamide
Solubility
Soluble in DMSO > 10 mM
Shipping Conditions
Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request
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