Products

Online Inquiry

Name

Email *

Phone *

Company/Institution

Country or Region

Quantity

Services & Products Interested *

Project Description

Our Products Cannot Be Used As Medicines Directly For Personal Use.

Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.

WZ3146

inquiry

Cat No.

CEI-0026

Description

WZ3146

CAS No.

1214265-56-1

Molecular Weight

464.95

Purity

>99%

Storage

2 years at -20 centigrade

Targets

EGFR(L858R)

Molecular Formula

C24H25ClN6O2

Solubility

In vitro

As an irreversible inhibitor, WZ3146 can inhibit EGFR(L858R) and EGFR(E746_A750) with IC50 of 2 nM and 2 nM, respectively. WZ3146 is profiled against Ba/F3 cells transformed with TEL fusions of BMX, BLK, JAK2 and JAK3. WZ4002, which possesses an ortho-methoxy group at the C2-aniline substituent, is more selective for EGFR than WZ3146.