Description
Vincristine Sulfate, a dimeric Vinca alkaloid, has been shown to bind to Tubulin via a protein self association reaction. This compound acts as a Tubuiln inhibitor by binding to sites at the ends of microtubules, which regulate the inhibition of Tubulin dimer addition to microtubule ends. Experiments have reported Vincristine Sulfate to demonstrate a capacity to suppress growth of proliferating cells through marked apoptosis and cell cycle arrest at G2/M. The cell death caused by this agent seems to result in a sustained accumulation of endogenous ceramide levels. Ceramide, has been proposed as a lipid second messenger with specific antiproliferative mediating responses. Vincristine Sulfate is an inhibitor of MAO. Vincristine Sulfate is also a substrate of PGP and CYP3A4.
Applications
A cell cycle arresting, apoptotic inducing alkaloid
Synonyms
22-Oxovincaleukoblastine Sulfate; Leurocristine Sulfate; Kyocristine; Lilly 37231; NSC 67574; Novopharm; Oncovin; Onkovin; VCR Sulfate; Vincasar PFS; Vincrisul
Molecular Formula
C46H56N4O10•H2SO4
Solubility
Soluble in water (25 mg/ml), ethanol, and methanol.
Substrates
PKA; CKII; PKCα
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