Description
A plant alkaloid that arrests the cell cycle in G2/M phase by blocking mitotic spindle formation. Inhibits normal microtubule assembly and causes aberrant tubulin polymerization. Blocks binding of tubulin to microtubule proteins. Induces apoptosis. Triggers Raf-1 activation, phosphorylation of Bcl-2 family proteins and induction of p53 expression. Cancer chemotherapeutic agent.
Alias
Vincaleukoblastine sulfate salt; VLB
Product Overview
A tubulin polymerrization inhibitor
Synonyms
Vincaleukoblastine sulfate salt; VLB
Molecular Formula
C₄₆H₅₈N₄O₉S.H₂SO₄
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