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UNC0638
Cat No.
CEI-0486
Description
Cell-permeable. UNC0638 is a potent G9a HMTase inhibitor, exhibiting an IC50 value of <15 nM in vitro. UNC0638 also inhibits GLP, a closely-related H3K9 HMTase, with an IC50 value of 19 nM, but is more than 10,000-fold selective against SET7/9 (a H3K4 HMTase), SET8 (a H4K20 HMTase), PRMT3, and SUV39H2. UNC0638 inhibits H3K9 dimethylation in MDA-MB231 cells with an IC50 value of 81 nM and demonstrates favorable separation of functional and toxic effect.
Appearance
White solid
Product Overview
Apotent G9a HMTase inhibitor
CAS No.
1255580-76-7
Molecular Weight
307.39
Purity
>98% by HPLC
Storage
-20 centigrade
Targets
EHMT2
Molecular Formula
C₃₀H₄₇N₅O₂
Chemical Name
2-Cyclohexyl-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine
Solubility
DMSO ( 1mg/ml)
Shipping Conditions
RT
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