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Tubastatin A hydrochloride
Cat No.
CEI-0994
Description
Tubastatin A is a potent HDAC6 inhibitor. It demonstrates over 1,000-fold selectivity against all other HDAC isoforms (IC50 >16 μM), excluding HDAC8 (IC50 = 0.9 μM). Tubastatin A induces -tubulin hyperacetylation at 2.5 μM in primary cortical neuron cultures. In a model of oxidative stress induced by glutathione depletion, it displays dose-dependent neuronal protection of primary cortical neuron cultures at 5-10 μM.
Abbr
Tubastatin A hydrochloride(HDAC6)
Alias
JM21, HD6
Appearance
White to off-white crystalline solid.
CAS No.
1310693-92-5
Molecular Weight
371.86
Storage
Store at or below -20 centigrade.
Synonyms
JM21, HD6
Targets
HDAC6
IC50
15 nM
Molecular Formula
C20H21N3O2 HCl
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