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Tipifarnib (Zarnestra)
Cat No.
CEI-0226
Description
Tipifarnib (Zarnestra) can inhibit farnesyltransferase with IC50 of 0.6 nM.
Alias
R115777
CAS No.
192185-72-1
Molecular Weight
489.4
Purity
>99%
Storage
2 years at -20centigrade Powder
Synonyms
R115777
Targets
farnesyltransferase
Molecular Formula
C27H22Cl2N4O
Chemical Name
(R)-6-(amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methylquinolin-2(1H)-one
Solubility
DMSO 14 mg/mL Water
In vitro
As an Tipifarnib (formerly known as R-1 15777), an inhibitor of RAS farnesylation, for the potential treatment of neoplasia. Tipifarnib can inhibit farnesyltransferase with IC50 of 0.6 nM. Tipifarnib is an oral, very potent, and highly selective FTI (farnesyltransferase inhibitors) with a relatively low toxicity pro?le. FTIs function by competitively inhibiting the addition of a farnesyl moiety to several important signaling molecules 3 and thus target multiple pathways, including the RAS pathway implicated in the pathogenesis of solid and hematologic malignancies.
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