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Project Description

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Tie2 kinase inhibitor

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Cat No.

CEI-0025

CAS No.

948557-43-5

Molecular Weight

439.53

Purity

>99%

Storage

2 years at -20centigrade Powder

Targets

Tie2 kinase

Molecular Formula

C26H21N3O2S

Chemical Name

4-(5-(6-methoxynaphthalen-2-yl)-2-(4-(methylsulfinyl)phenyl)-1H-imidazol-4-yl)pyridine

Solubility

DMSO 35 mg/mL， Water

In vitro

Tie2 kinase inhibitor exhibits a moderate inhibitory activity against Tie2 tyrosine kinase. Tie2 kinase inhibitor also shows moderate cellular activities with IC50 of 232 nM in HEL cells. Furthermore, Tie2 kinase inhibitor has a remarkable selectivity for Tie2 over p38 (IC50=50 uM) and a >10-fold selectivity over VEGFR2, VEGFR3, and PDGFR1beta.