Products
Online Inquiry
Our Products Cannot Be Used As Medicines Directly For Personal Use.
Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.
TG101348 (SAR302503)
Cat No.
CEI-0192
Description
TG-101348 (SAR302503) can selectively inhibit JAK2 with IC50 of 3 nM.
CAS No.
936091-26-8
Molecular Weight
524.68
Purity
>99%
Storage
2 years at -20 centigrade
Targets
JAK2
Molecular Formula
C27H36N6O3S
Chemical Name
N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)pyrimidin-4-ylamino)benzenesulfonamide
Solubility
DSMO 105 mg/mL Water
In vitro
TG-101348 also significantly inhibits JAK2 V617F, Flt3, and Ret with IC50 of 3 nM, 15 nM, and 48 nM, respectively. TG-101348 also inhibits proliferation of parental Ba/F3 cells to a comparable level, with IC50 of ~420 nM. TG101348 treatment decreases GATA-1 expression, which is associated with erythroid-skewing of JAK2V617F+ progenitor differentiation, and inhibits STAT5 as well as GATA S310 phosphorylation.
In vivo
Oral administration of TG101348 (120 mg/kg) significantly inhibits PV progenitor erythroid differentiation in vivo.
Download
Download Datasheet