Products
Online Inquiry
Our Products Cannot Be Used As Medicines Directly For Personal Use.
Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.
TG100-115
Cat No.
CEI-0130
Description
TG100-115 can inhibit PI3K-gamma and PI3K-delta with IC50 of 83 nM and 235 nM.
CAS No.
677297-51-7
Molecular Weight
346.34
Purity
>99%
Storage
2 years at -20centigrade Powder
Targets
PI3K-gamma, PI3K-delta
Molecular Formula
C18H14N6O2
Chemical Name
6,7-Bis(3-hydroxyphenyl)pteridine-2,4-diamine
Solubility
DMSO 9 mg/mL Water
In vitro
TG100-115 can inihbit PI3K-gamma and PI3K-delta with IC50 of 83 nM and 235 nM. TG100-115 has no effects on EC proliferation even at relatively high concentrations (up to 10 uM).
In vivo
TG100-115 can block histamine-induced permeability. In a rodent hindpaw model, TG100-115 strongly antagonized both the edema and leukocyte Infiltration. Blockade was seen with TG100-115 doses as low as 0.5 mg/kg and persisted over a period of several hours. But TG100-115 does not block VEGF-induced angiogenesis in vivo.
Download
Download Datasheet