Description
TG100-115 can inhibit PI3K-gamma and PI3K-delta with IC50 of 83 nM and 235 nM.
Storage
2 years at -20centigrade Powder
Targets
PI3K-gamma, PI3K-delta
Molecular Formula
C18H14N6O2
Chemical Name
6,7-Bis(3-hydroxyphenyl)pteridine-2,4-diamine
Solubility
DMSO 9 mg/mL Water
In vitro
TG100-115 can inihbit PI3K-gamma and PI3K-delta with IC50 of 83 nM and 235 nM. TG100-115 has no effects on EC proliferation even at relatively high concentrations (up to 10 uM).
In vivo
TG100-115 can block histamine-induced permeability. In a rodent hindpaw model, TG100-115 strongly antagonized both the edema and leukocyte Infiltration. Blockade was seen with TG100-115 doses as low as 0.5 mg/kg and persisted over a period of several hours. But TG100-115 does not block VEGF-induced angiogenesis in vivo.
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