Products

Enzymes for Research, Diagnostic and Industrial Use

Products
Online Inquiry

Our Products Cannot Be Used As Medicines Directly For Personal Use.

24 hour
Promise

Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.

Temsirolimus (Torisel)

Cat No.
CEI-0113
Description
Temsirolimus (Torisel) can inhibit mTOR with IC50 of 1.76 uM.
Alias
CCI-779
CAS No.
162635-04-3
Molecular Weight
1030.29
Purity
>99%
Storage
2 years at -20centigrade Powder
Synonyms
CCI-779
Targets
mTOR
Molecular Formula
C56H87NO16
Chemical Name
Rapamycin, 42-[3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate]
Solubility
DMSO 75 mg/mL Water 1 mg/ml Ethanol 75 mg/mL
In vitro
As a mTOR inhibitor, temsirolimus (cell cycle inhibitor-779, CCI 779) can inhibit mTOR with IC50 of 1.76 uM. Temsirolimus (cell cycle inhibitor-779, CCI 779) is an ester analogue of sirolimus for the treatment of cancer, multiple sclerosis and rheumatoid arthritis. Temsirolimus binds to the cytosolic protein, FKBP, which subsequently inhibits mTOR (mammalian target of rapamycin). Inhibition of mTOR blocks a number of signal transduction pathways that suppress translation of several key proteins regulating the cell cycle. By inhibiting mTOR, temsirolimus lead to a cell cycle block at the G1 phase.
In vivo
In animal models of human cancers, temsirolimus inhibited the growth of a diverse range of cancer types even when an intermittent dosing schedule was used. Temsirolimus also appears to have potential for the blockade of inflammatory responses associated with autoimmune and rheumatic diseases by inhibiting T-cell proliferation.

Our Products Cannot Be Used As Medicines Directly For Personal Use.

0
Click unfold / close
Inquiry Basket
Delete selected Quote Check Out
Decide to move out of the shopping cart?
Sure No, Back

Please choose product!

< Go Back
You have already added to buy this product