Description
TAK-715 is a potent specific inhibitor of the p38α MAP kinase with an IC50 value of 7.1 nM. It inhibited TNF-α production by 87.6% in mice at 10 mg/kg, po and has potential for treatment of TNF-α mediated inflammatory diseases such as rheumatoid arthriti.
Abbr
TAK-715(MAPK14, TNF)
Alias
RP1-179N16.5, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, P38alpha
Product Overview
p38α MAP kinase
Stability
2 years -20 centigrade Powder
1 month -4 centigrade in DMSO
More than one month -80 centigrade in DMSO
Synonyms
RP1-179N16.5, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, P38alpha
Targets
p38alpha, TNF-alpha
Molecular Formula
C24H21N3OS
Chemical Name
N-(4-(2-ethyl-4-m-tolylthiazol-5-yl)pyridin-2-yl)benzamide
Solubility
DMSO > 112mg/mL Water >1mg/mL Ethanol > 4mg/mL
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