Products
Online Inquiry
Our Products Cannot Be Used As Medicines Directly For Personal Use.
Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.
SU-4312
Cat No.
CEI-0976
Description
Potent and selective inhibitor of VEGF receptor tyrosine kinase (Flk-1, KDR). Inhibits unactivated kinase 100-fold greater (IC50=0.04 uM) than activated kinase (IC50=4.0 uM ). Weak inhibitor of PDGF receptor tyrosine kinase (IC50=19.4 uM). Inhibits endothelial cell activation and angiogenesis in a mouse model of Alzheimers disease.
Abbr
SU-4312(KDR, PDGFRB)
Alias
1. 3-(4-Dimethylaminobenzylidene)-1, 3-dihydroindol-2-one 2. DMBI
Appearance
Orange powder
Product Overview
VEGFR; PDGFR inhibitor
CAS No.
5812-07-7
Molecular Weight
264.3
Purity
>98% (TLC); NMR (Conforms)
Synonyms
1. 3-(4-Dimethylaminobenzylidene)-1,3-dihydroindol-2-one 2. DMBI
Targets
VEGFR, PDGFR
Molecular Formula
C17H16N2O
Solubility
May be dissolved DMSO (25 mg/ml)
Download
Download Datasheet